You will work on a project that aims to unravel important mechanisms that contribute to inflammatory bowel disease in humans. Work is based on our previous findings that monocytes and macrophages in the intestine of patients with active inflammatory bowel disease have diminished expression of a key cell surface receptor called integrin αvβ8, which is a crucial activator of the anti-inflammatory cytokine TGFβ. Our preliminary data now suggest that soluble mediators are responsible for downregulation of this pathway in the inflamed intestine, and this project now aims to characterise the molecules and mechanisms responsible.
The project will involve liaison with gastroenterologists in local hospitals, acquisition of human blood and tissue samples, and analysis of cells and molecules by flow cytometry and other analytical techniques. The project aims to provide a step-change in our understanding of how monocytes and macrophages become dysregulated in patients with inflammatory bowel disease.
Essential requirements/skills for the post include:
Start date: As close to 1st October 2021 as possible
As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Blended working arrangements may be considered
Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.
Enquiries about the vacancy, shortlisting and interviews:
Name: Professor Mark Travis
Email: mark.travis@manchester.ac.uk
General enquiries:
Email: hrservices@manchester.ac.uk
Technical support:
https://jobseekersupport.jobtrain.co.uk/support/home
This vacancy will close for applications at midnight on the closing date.
Please see the link below for the Further Particulars document which contains the person specification criteria.
