The extracellular environment of cells alters enormously particularly during ageing, injury and certain diseases. For example, the properties of the ECM influences tumour progression, and stiffening of ECM causes fibrosis, which in turn can lead to malfunctioning of the affected tissues. Intriguingly, cells produce and simultaneously respond to these environmental changes. This project is aimed to shed light into this process by elucidating the mechanism of ECM sensing and remodeling.
The appointment is for 36 month full-time and the appointed person would be expected to perform routine laboratory duties and be actively engaged in reading of scientific literature relating to the project.
The essential skills for this project are: Cell culture including transfections, Advanced Fluorescence microscopy (i.e. FRAP, photoactivation and super-resolution), Molecular biology (cloning & site directed mutagenesis approaches), Biochemistry, BioID mass spectrometry and network analysis. The applicant should have also substantial knowledge in cell adhesion mechanisms.
As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.
Enquiries about the vacancy, shortlisting and interviews:
Name: Christoph Ballestrem
Email: Christoph.ballestrem@manchester.ac.uk
General enquiries:
Email: hrservices@manchester.ac.uk
Technical support:
https://jobseekersupport.jobtrain.co.uk/support/home
This vacancy will close for applications at midnight on the closing date.
Please see the link below for the Further Particulars document which contains the person specification criteria.
