Applications are invited for a postdoctoral scientist to work on an exciting project focused on understanding the solution behaviour of concentrated monoclonal antibodies. The study will involve use of NMR spectroscopy (1H and 19F) and protein labelling for characterizing protein solutions and mixtures thereof. A key outcome of the work will be multi-component formulations that can access ultra-high protein concentrations while minimizing high viscosities and particle formation. You will have a PhD (or equivalent) in NMR spectroscopy, biochemistry and/or biophysics, or in a related discipline. Experience is required in protein NMR spectroscopy and basic protein chemistry (protein purification, concentration and labelling, e.g. with paramagnetic or fluorine labels).
The project is funded by MedImmune, the global biologics research and development arm of AstraZeneca, and is part of a collaborative initiative centred on biopharmaceuticals with the Centre of Excellence in Biopharmaceuticals (COEBP, http://www.coebp.ls.manchester.ac.uk). The research project will be largely based in the Manchester Institute of Biotechnology (MIB), with placements (up to 25% FTE) at MedImmune’s R&D site in Cambridge, UK. The NMR Facility in the MIB is equipped with 800, 600 and 500 MHz Bruker spectrometers, with cryoprobes. The Formulation Laboratories at MedImmune, Cambridge, house all instrumentation and facilities necessary for a modern, large biopharmaceutical company.
You will be motivated and able to work independently. You will be responsible for intellectual steer and input to the research, experimental design and organisation, data interpretation and dissemination, meeting project deadlines and co-ordination between industry and academic supervisors.
The full time post is available from October onwards and will be offered on a fixed-term contract for a period of 12 months, with the possibility for renewal for further 12 months after 12-month review.
Molecular Systems is committed to promoting equality and diversity, including the Athena SWAN charter for promoting women’s careers in STEMM subjects (science, technology, engineering, mathematics and medicine) in higher education. They received a Silver Award in 2009 for their commitment to the representation of women in the workplace and we particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit http://www.wils.ls.manchester.ac.uk/athenaswanawards/.
The Faculty of Medical and Human Sciences/Life Sciences will form part of a newly created Faculty of Biology, Medicine and Health from 1st August 2016. This post will transfer to the new structure on that date and details of the where the post sits within the new structure will be provided to successful candidates in their letter of appointment.
Enquiries about the vacancy, shortlisting and interviews:
Dr Alexander Golovanov
Tel: 0161 306 5813
Tel: 0161 275 4499
Tel: 01565 818 234
Date of external posting: Monday 20 June 2016
This vacancy will close for applications at midnight on the closing date.