Our Faculty’s integrated structure, and state-of-the-art research facilities, enable a truly translational approach to biology, medicine and health, and provide both staff and students with a unique opportunity to have a very real and positive impact on people’s lives.
A postdoctoral vacancy is available within an active and well-funded research team to investigate the structure and function of multi-molecular complexes responsible for extracellular matrix organisation in the context of inflammatory processes and reproductive biology.
The project will use cryo-electron microscopy (cryoEM), in combination with other quantitative biophysical techniques, to determine the high-resolution structures of protein complexes that act as 'crosslinking nodes', which stabilize matrices containing the simple polysaccharide hyaluronan. These complexes are essential for ovulation and fertilization in mammals and also form wherever there is inflammation, e.g. in articular joints during arthritis. Detailed structural insights will enable the targeted modulation of hyaluronan cross-linking, to interfere with pathological matrix development and to generate matrices with tailored properties in vitro, e.g. for applications in regenerative medicine and human fertility treatments.
We are seeking a post-doctoral researcher experienced in single-particle cryoEM analysis of protein structure. Knowledge of recombinant protein production, other structural techniques (e.g. Small-Angle X-ray Scattering (SAXS) and X-ray crystallography) and biophysical analysis of protein-ligand interactions are also desirable.
This is a full-time position, funded by the BBSRC, and is available from 1st December 2019, or as soon as possible thereafter, for up to three years.
The School is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance. We particularly welcome applications from women for this post. All appointment will be made on merit. For further information, please visit: https://www.bmh.manchester.ac.uk/about/equality/
Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.
Enquiries about the vacancy, shortlisting and interviews:
Name: Professor Anthony J Day
TeL: 0161 2751495
Tel: 0161 850 2004
Tel: 0161 275 4499
This vacancy will close for applications at midnight on the closing date.