Fibrosis is a major contributor to multiple serious disorders including heart failure, atrial fibrillation, atherosclerosis, hypertension, cancer, lung, liver and kidney failure. A major bottleneck has been our limited understanding of physiological tissue homeostasis that maintains the organization and stiffness of healthy tissues. Without understanding the normal mechanisms, data on the transition to fibrosis are difficult to interpret. The goal of this project is to elucidate the pathways by which cells sense the properties of their extracellular matrix and adjust rates of matrix synthesis, assembly and degradation to keep those properties constant, and how these mechanisms are overcome in fibrosis. The successful candidate will work with Professor Martin Schwartz to elucidate how cellular stiffness sensing pathways regulate matrix synthesis and turnover. These studies will utilize a combination of biophysical, cell biological and tissue engineering approaches to address these questions.
The ideal candidate has obtained a PhD (or equivalent) degree in genetics, cell biology, molecular biology, cancer biology or related discipline with experience related to the above areas. You will be based in the lab of Martin Schwartz in the vibrant interdisciplinary environment of the Wellcome Trust Centre for Cell-Matrix Research (www.wellcome-matrix.org/) at the University of Manchester.
The School is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance. We particularly welcome applications from women for this post. All appointment will be made on merit. For further information, please visit:
Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies
Enquiries about vacancy shortlisting and interviews:
Name: Martin Schwartz
Tel: 0161 275 4499
Tel: 0161 850 2004
This vacancy will close for applications at midnight on the closing date