Accessibility Tools

Job details

Research Associate
Oxford Road, Manchester

Job reference: SAE-020555

Location: Oxford Road, Manchester

Closing date (DD/MM/YYYY): 02/12/2022

Salary: £34,308 - £42,155 per annum depending on experience

Employment type: Fixed Term

Faculty/Organisation: Science and Engineering

Division: Department of Chemistry

Hours per week: Full time

Contract Duration: 36 months

School / Directorate: School of Natural Sciences


A three-year post-doctoral position funded by a BBSRC IPA grant is available to study the biochemistry, structure and biotechnological application of the prFMN dependent enzyme phenol phosphate carboxylase (PPC).  The research is carried out in the Manchester Institute for Biotechnology (MIB).  The goal of the project is to understand how this prFMN-dependent enzyme achieves irreversible carboxylation, using structural biology, kinetic and computational approaches. In recent years, the Leys group has been at the forefront of the discovery and fundamental understanding of these ubiquitous bacterial enzymes. Recent advances in the evolution and application of these enzymes have been made by the group, leading to a comprehensive insight into the (de)carboxylases. Our focus is now on those prFMN enzymes that function as obligate carboxylases as well as the development of novel prFMN-dependent systems. ​​​​​​​

Overall, Purpose of the Job

The post-doctoral fellow will study the prFMN dependent PPC that function as carboxylases under physiological conditions, with the ultimate aim to capture CO2 as a building block.  The fellow will take advantage of a wealth of preliminary data already gathered on these systems by our group, enabling them to make rapid progress with validating our present hypothesis. The fellow will take part in preparing the manuscripts describing these results for publication and will work collaboratively with the wider biocatalysts groups at the MIB.

As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status.  All appointments are made on merit.

Our University is positive about flexible working – you can find out more here

Blended working arrangements may be considered

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.

Enquiries about the vacancy, shortlisting and interviews:

Name: Professor David Leys


General enquiries:


Technical support:

This vacancy will close for applications at midnight on the closing date.

Please see the link below for the Further Particulars document which contains the person specification criteria.